发明名称 INHIBITOR OF SERINE PROTEASE (ESPECIALLY, HCVNS3-NS4A PROTEASE)
摘要 PROBLEM TO BE SOLVED: To provide an effective anti-HCV treatment. SOLUTION: The compound of formula (I), its pharmaceutically acceptable salt, or their mixture inhibits serine protease activity, especially, inhibits the activity of hepatitis C virus NS3-NS4A protease. Thereby, they act as inhibiting the life circle of the hepatitis C virus, and are useful as anti-viral agents. Further a pharmaceutically acceptable composition containing the compound is provided, and it is used in any of exovivo uses or administration for a patient suffering from HCV infection. The process for preparing the compound is also provided. Also, the method for treating the HCV infection in the patients is provided by administering a pharmaceutical composition containing the compound. COPYRIGHT: (C)2011,JPO&INPIT
申请公布号 JP2011068655(A) 申请公布日期 2011.04.07
申请号 JP20100243570 申请日期 2010.10.29
申请人 VERTEX PHARMACEUTICALS INC 发明人 FARMER LUC J;PERNI ROBERT P;BHISETTI GOVINDA RAO;WILSON KEITH P
分类号 C07K5/10;A61K31/401;A61K31/407;A61K31/4155;A61K31/425;A61K31/4745;A61K31/4965;A61K38/04;A61K38/55;A61K45/00;A61P31/14;A61P43/00;C07D403/12;C07D417/12;C07D471/02;C07K5/083;C07K5/087 主分类号 C07K5/10
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