发明名称 |
FUSION POLYPEPTIDES CAPABLE OF ACTIVATING RECEPTORS |
摘要 |
<p>A fusion polypeptide comprising (A)x-M-(A')y, wherein A and A' are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A' may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different ScFv fragments, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10.</p> |
申请公布号 |
EP1709081(B1) |
申请公布日期 |
2011.04.06 |
申请号 |
EP20050711471 |
申请日期 |
2005.01.14 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
FANDL, JAMES;CHEN, GANG;PAPADOPOULOS, NICHOLAS;ALDRICH, THOMAS, H. |
分类号 |
C07K16/28;C07H21/04;C07K14/515 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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