| 摘要 |
Provided is a method for identifying a subject belonging to a group responding to a blockade of alpha2beta1 integrin receptors as determined by a decrease in platelet aggregation, comprising a) determining a single nucleotide polymorphism (SNP) C/T located at base pair 807 of alpha2 integrin cDNA, in a sample obtained from said subject, b) measuring the expression level of alpha2beta1 integrin on platelets obtained from a subject having a CT807 genotype, and c) identifying as a subject responding to the blockade of alpha2beta1 integrin receptors , a subject having either a TT807 genotype, or having a CT807 genotype combined with a high expression level of alpha2beta1 integrin, wherein high expression level of aplha2beta1 integrin means a statistically significant increase in said expression level as compared to the expression level of alpha2beta1 integrin in subjects having a CC807 genotype.
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