ALPHA-HELIX MIMETIC USING A 2,5-OLIGOPYRIMIDINE SCAFFOLD
摘要
Alpha-helix mimetics and associated methods of making are provided. These compounds are constructed using a 2,5-oligopyrimidine scaffold. The semi-rigid scaffold holds individual side chain-like residues in orientations that mimic the orientations of side chain residues of an ?-helical protein domain. The new scaffold is easier to make than previous scaffolds and has much more favorable physical properties than previous alpha-helix mimics. The amphiphilic alpha-helix mimetics have application for making libraries and for treating diseases or conditions effected by the inhibition or disruption of interactions with the alpha helix of a protein.
申请公布号
WO2010083501(A3)
申请公布日期
2011.03.31
申请号
WO2010US21356
申请日期
2010.01.19
申请人
UNIVERSITY OF SOUTH FLORIDA;H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.;MCLAUGHLIN, MARK L.;ANDERSON, LAURA;ZHOU, MINGZHOU
发明人
MCLAUGHLIN, MARK L.;ANDERSON, LAURA;ZHOU, MINGZHOU