| 摘要 |
The present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MPER). The present invention also relates to a cell culture system, more specifically, to a method of rendering chronic lymphocytic leukemia B-cells immortal and to a method of isolating anti-viral antibodies from clones of such cells.
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| 申请人 |
DUKE UNIVERSITY;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SEC RETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH |
发明人 |
HAYNES, BARTON F.;TOMARAS, GEORGIA;SHEN, SHAUNNA;DIMITROV, DIMITER S.;ZHU, ZHONGYU;HWANG, KWAN-KI;CHIORAZZI, NICHOLAS |
