发明名称 |
ASSAY FOR DETERMINING HEALTH OF CD8+ T CELLS |
摘要 |
<p>A method of determining if a subject's CD8+ T-cells functionally recognize an HLA-E/Hsp60sp target structure comppsmg a) contacting a sample of the subject's CD8+ T-cells with a HLA-E+ cell loaded with Hsp60sp, b) quantifying proliferation of the contacted HLA-E+ cell, c) contacting a sample of the subject's CD8+ T-cells with a HLA-E+ cell which is loaded with a peptide which does not bind to HLA- E, d) quantifying proliferation of the HLA-E+ cell loaded with the peptide which does not bind to HLA-E following contact with the subject's CD8+ T-cells, e) comparing the proliferation quantified in step d) with the proliferation quantified in step b)</p> |
申请公布号 |
WO2011028257(A1) |
申请公布日期 |
2011.03.10 |
申请号 |
WO2010US02341 |
申请日期 |
2010.08.24 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;JIANG, HONG;CHESS, LEONARD |
发明人 |
JIANG, HONG;CHESS, LEONARD |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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