| 摘要 |
The present invention relates to a support onto which a set of probes is applied wherein the set comprises: (a) probes capable of specifically hybridising with nucleic acids encoding fucosyltransferases; (b) probes capable of specifically hybridising with nucleic acids encoding galactosyltransferases; (c) probes capable of specifically hybridising with nucleic acids encoding N-acetylglucosaminyltransferases; (d) probes capable of specifically hybridising with nucleic acids encoding N-acetylgalactosaminyltransferases; (e) probes capable of specifically hybridising with nucleic acids encoding sialyltransferases; (f) probes capable of specifically hybridising with nucleic acids encoding sugar sulfotransferases; (g) probes capable of specifically hybridising with nucleic acids encoding lectins; (h) probes capable of specifically hybridising with nucleic acids encoding selectins; (i) probes capable of specifically hybridising with nucleic acids encoding fucosidases; (j) probes capable of specifically hybridising with nucleic acids encoding neuraminidases (sialidases); (k) probes capable of specifically hybridising with nucleic acids encoding nucleotide sugar epimerases; (l) probes capable of specifically hybridising with nucleic acids encoding sugar kinases; (m) probes capable of specifically hybridising with nucleic acids encoding sugar epimerases; (n) probes capable of specifically hybridising with nucleic acids encoding sugar transporters; and (o) probes capable of specifically hybridising with nucleic acids encoding enzymes of the fucose or sialic acid metabolism. The invention further relates to a kit which comprises the probes of the invention and the use of the support or the kit of the invention for the quantitative determination of expression profiles in a sample obtained from a cell, a tissue or an organism. The present invention further relates to a diagnostic composition and the use of the set of probes of the invention for the preparation of diagnostic compositions or of a diagnostic apparatus for the diagnosis of tumours, inflammatory and/or neurological diseases.
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