发明名称 |
DNA VACCINES FOR DOGS |
摘要 |
<p>The invention aims at improving the efficacy and protection induced by DNA vaccination against viruses of the family of Paramyxoviridae and against the herpes virus, in pets and sport animals. The improvement of DNA vaccination is achieved either by formulating the vaccine with a cationic lipid containing a quaternary ammonium salt, DMRIE, or by modifications in the nucleotide sequence coding for the antigen of interest in particular of deletions of the fragment of the nucleotide sequence coding for the transmembrane domain of the antigen of interest, and/or insertions of introns and/or insertions of nucleotide sequences coding for the signal peptides, or by adding GM-CSF, or by combinations thereof. The invention also concerns the resulting vaccines.</p> |
申请公布号 |
EP1185662(B1) |
申请公布日期 |
2011.03.02 |
申请号 |
EP20000940474 |
申请日期 |
2000.06.08 |
申请人 |
MERIAL |
发明人 |
FISCHER, LAURENT, JEAN-CHARLES;BARZU-LE ROUX, SIMONA;AUDONNET, JEAN-CHRISTOPHE, FRANCIS |
分类号 |
A61K39/175;C12N15/09;A61K35/74;A61K38/00;A61K39/00;A61K39/12;A61K39/145;A61K39/155;A61K39/193;A61K39/205;A61K39/215;A61K39/23;A61K39/245;A61K39/265;A61K39/27;A61K39/295;A61K39/39;A61K48/00;A61P31/12;A61P31/16;A61P31/22;C07K14/535;C12N15/27;C12N15/38 |
主分类号 |
A61K39/175 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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