Antibody drug conjugates and methods

摘要

Disclosed is a composition comprising a mixture of antibody-drug conjugate compounds, wherein each antibody-drug conjugate compound comprises an antibody covalently attached by a linker to one or more maytansinoid drug moieties, the compound having Formula I: Ab-(L-D)p or a pharmaceutically acceptable salt or solvate thereof, wherein: Ab is a human or humanized antibody which binds to CD22; L is a linker selected from a number of specified structures and p = 1-8. (62) Divided Out of 551180