发明名称 |
Nucleic acids encoding growth hormone with a modified RSP sorting signal |
摘要 |
The invention provides a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides a nucleic acid molecule encoding a GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell.
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申请公布号 |
US7888070(B2) |
申请公布日期 |
2011.02.15 |
申请号 |
US20070850947 |
申请日期 |
2007.09.06 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
LOH YOKE PENG;CAWLEY NIAMH;BAUM BRUCE J.;SNELL CHRISTOPHER R. |
分类号 |
C07H21/04;A61K38/00;C07K14/61;C12N5/16;C12N15/18;C12N15/63 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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