发明名称 |
THERAPEUTIC AGENT FOR ANAEROBIC DISEASES |
摘要 |
A conventional shuttle vector constructed by fusing an E. coli-derived plasmid and a transformant-derived plasmid functions in both E. coli and the transformant bacterium, and there exists no expression vector that functions only in a non-E. coli transformant. The present invention provides an plasmid expression vector comprising (1) a plasmid replication unit that functions in an anaerobic microorganism other than E. coli and (2) a protein expression unit formed from DNA coding for a protein having target activity and a DNA fragment containing a promoter and a terminator that function in the anaerobic microorganism. The expression vector of the present invention is capable of being replicated only in a transformant, eliminating the risk of the replication of the transformant gene in other pathogenic or aerobic bacterium, providing an extremely safe and reliable vector and gene transporter for therapeutic application. |
申请公布号 |
EP2280717(A1) |
申请公布日期 |
2011.02.09 |
申请号 |
EP20090733604 |
申请日期 |
2009.04.17 |
申请人 |
ANAEROPHARMA SCIENCE INC. |
发明人 |
SASAKI, TAKAYUKI;SHIMIZU, HITOMI;SHIMATANI-SHIBATA, YUKO;YONEKURA, HIROMI |
分类号 |
A61K35/74 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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地址 |
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