发明名称 |
TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS |
摘要 |
Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents a group selected from H, CF3, and C1-6 alkyl (optionally substituted by C1-6 alkyloxy or triazolyl); R2 represents halo; Ring A represents a 5- or 6-membered heterocyclic ring containing at least one N atom (the ring being optionally bridged with two or more carbon atoms); R3 represents a 5- or 6-membered heterocyclic ring containing at least one atom selected from N, O or S, the heterocyclic ring being optionally substituted by one or more groups selected from C1-6 alkyl, oxo or NH2, the heterocyclic ring being further optionally fused to a 5- or 6-membered aryl or heterocyclic ring containing at least one atom selected from N, O or S, the fused aryl or heterocyclic ring being substituted by one or more halo atoms; are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
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申请公布号 |
CA2605899(C) |
申请公布日期 |
2011.02.08 |
申请号 |
CA20062605899 |
申请日期 |
2006.04.18 |
申请人 |
PFIZER LIMITED |
发明人 |
BRYANS, JUSTIN STEPHEN;BUNNAGE, MARK EDWARD;JOHNSON, PATRICK STEPHEN;MASON, HELEN JANET;ROBERTS, LEE RICHARD;RYCKMANS, THOMAS;STOBIE, ALAN;UNDERWOOD, TOBY JAMES |
分类号 |
C07D401/14;A61K31/4196;A61P25/00;C07D413/14;C07D417/14;C07D471/04;C07D487/04;C07D498/04;C07D513/04 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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