发明名称 |
Process for making trans-isocarveol |
摘要 |
A process for making trans-isocarveol, an intermediate useful in the manufacture of perillyl alcohol, is disclosed. The process comprises isomerizing a mixture comprising cis-limonene oxide (cis-LMO) and trans-limonene oxide (trans-LMO) in the presence of a phenolic modifier and a chromium catalyst. The process is performed at a temperature less than 220° C. to convert more than 50% of the cis-LMO to trans-isocarveol and less than 50% of the trans-LMO to cis-isocarveol. We surprisingly found that a mixture of cis- and trans-LMO can be selectively isomerized to produce mostly trans-isocarveol, which we discovered is the preferred isomer for making perillyl alcohol by direct isomerization.
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申请公布号 |
US7884252(B1) |
申请公布日期 |
2011.02.08 |
申请号 |
US20100799119 |
申请日期 |
2010.04.19 |
申请人 |
LYONDELLBASELL FLAVORS & FRAGRANCES, LLC |
发明人 |
KOLOMEYER GENNADIY G.;FERONE DOUGLAS A. |
分类号 |
C07C35/18 |
主分类号 |
C07C35/18 |
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