摘要 |
Disclosed herein is a formulation capable of enhancing thermostability and shelf- life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae (I), wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms; an inorganic salt; glutamic acid or a salt thereof; a polyol; a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH3)3NO. The formulation is useful for vaccine stabilization. |
申请人 |
XCELLEREX, INC.;SUN, TIANXIAO;LEVESQUE, PHILIP, M.;BROWN, ALICJA, T.;LEE, CYNTHIA, K. |
发明人 |
SUN, TIANXIAO;LEVESQUE, PHILIP, M.;BROWN, ALICJA, T.;LEE, CYNTHIA, K. |