发明名称 |
Delivery system |
摘要 |
A vector for delivering a foreign gene to a target cell for expression of the foreign gene is provided. The vector comprises a (-) sense RNA genome contained within a ribonucleoprotein complex within a virus-like particle constituted from structural proteins of a (-) sense RNA virus. The (-) sense RNA genome includes one or more foreign genes but does not include genes for replication of the (-) sense RNA virus. Methods of preparing the vector are disclosed, as well as pharmaceutical compositions containing the vector, and methods of delivering the expression product of the foreign gene to a target cell. |
申请公布号 |
ZA9307164(B) |
申请公布日期 |
1994.05.23 |
申请号 |
ZA19930007164 |
申请日期 |
1993.09.27 |
申请人 |
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION |
发明人 |
PETER JOHN WALKER;CHRISTOPHE JEAN PREHAUD;JEFF ALEXANDER COWLEY |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K48/00;A61P31/12;C07H21/04;C07K14/145;C12N7/04;C12N15/86;C12N15/866;C12N15/87 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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