发明名称 |
N-BUTYLAMIDE 2-ANILINO-6,7-DIHYDRO-5H-PYRINDINE-3- CARBOXYLIC ACID HAVING ANTI-INFLAMMATORY ACTIVITY |
摘要 |
FIELD: chemical industry. SUBSTANCE: novel n-butyl- amide-2-anilino-6,7-dihydro-5H-pyrindine-3-carboxylic acid of formula I: <EMI ID=0.22 HE=18 WI=42 TI=CHI>. Compound is prepared by reacting n-butylamine 2-chloro-6,7-dihydro-5H-pyrindine-5- carboxylic acid with aniline hydrochloride in butanol C<SB>19</SB>H<SB>23</SB>N<SB>3</SB>O, mp 132-134 C. Compound (I) has antiinflammatory activity. Antiinflammatory activity of compound (I) in 50 ml/kg is by 1.4 times higher than that of orthophene. ZD<SB>50</SB> is more than 500 mg/kg. EFFECT: improved properties of the title compound. 2 ex, 1 tbl |
申请公布号 |
RU2128651(C1) |
申请公布日期 |
1999.04.10 |
申请号 |
RU19970110472 |
申请日期 |
1997.06.18 |
申请人 |
PERMSKAJA GOSUDARSTVENNAJA FARMATSEVTICHESKAJA AKA |
发明人 |
GALEEVA R.N.;GAVRILOV M.JU.;NAZMETDINOV F.JA.;KOLLA V.EH.;KON'SHIN M.E. |
分类号 |
C07D221/04;A61K31/44;A61K31/4425;A61P29/00 |
主分类号 |
C07D221/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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