摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method for synthesis of 2-hydroxy-6-isopropenyl-3-methyl-cyclohex-3-enone, which can be used in asymmetric synthesis, for example in synthesis of chiral ligands which can be used in the pharmaceutical industry. The method involves isomerisation of verbenone epoxide in supercritical carbon dioxide with addition of isopropyl alcohol at temperature 463-513 K and pressure 140-150 atm. ^ EFFECT: high rate and efficiency of the process with continuous synthesis of the end product and controlled selectivity of synthesis. ^ 2 cl, 1 tbl, 1 dwg, 4 ex |