| 发明名称 |
2-PHENYL SUBSTITUTED IMIDAZOTRIAZINONES AS PHOSPHODIESTERASE INHIBITORS |
| 摘要 |
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
|
| 申请公布号 |
US2011009367(A1) |
申请公布日期 |
2011.01.13 |
| 申请号 |
US20100717443 |
申请日期 |
2010.03.04 |
| 申请人 |
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT |
发明人 |
NIEWOEHNER ULRICH;NIEWOEHNER MARIA;ES-SAYED MAZEN;HANING HELMUT;SCHENKE THOMAS;SCHLEMMER KARL-HEINZ;KELDENICH JOERG;BISCHOFF ERWIN;PERZBORN ELISABETH;DEMBOWSKY KLAUS;SERNO PETER;NOWAKOWSKI MARC |
| 分类号 |
A61K31/53;A61K31/5375;A61K31/5377;A61K31/541;A61K31/55;A61K31/551;A61K31/662;A61K31/683;A61P9/00;A61P9/10;A61P11/08;A61P13/00;A61P13/02;A61P13/08;A61P13/10;A61P15/00;A61P15/10;A61P43/00;C07D;C07D487/04;C07D491/113;C07D519/00;C07F9/6561 |
主分类号 |
A61K31/53 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
