发明名称 |
METHODS FOR DIAGNOSING A BIPOLAR DISORDER AND UNIPOLAR DISORDER |
摘要 |
Changes that occur in Na+K+ ATPase regulation and therefore in the membrane potential in cells from bipolar individuals, as compared to cells from unaffected control individuals, are utilized to provide a diagnostic assay for bipolar disorder. The diagnostic assay may also or instead exploit the similarity of cells from bipolar patients to those of people already known to have bipolar disorder. A similar diagnostic assay is provided for diagnosing unipolar disorder. The diagnostic assays may further involve manipulation of membrane potential by incubation of cells in K+-free buffer and/or incubation with one or more compounds that alter Na+K+ ATPase activity. Although a variety of cells may be used, the diagnostic assays preferably employ lymphoblasts or whole blood cells.
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申请公布号 |
CA2544429(C) |
申请公布日期 |
2011.01.04 |
申请号 |
CA20042544429 |
申请日期 |
2004.10.26 |
申请人 |
FREE STATE DIAGNOSTICS, LLC |
发明人 |
THIRUVENGADAM, ALAGU P.;CHANDRASEKARAN, KRISH |
分类号 |
G01N33/48;C12Q;C12Q1/00;C12Q1/34;G01N33/483;G01N33/50;G06F19/00 |
主分类号 |
G01N33/48 |
代理机构 |
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地址 |
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