发明名称 |
METHODS FOR THE DETECTION AND QUANTITATION OF THE P95 COMPONENT OF HER2/NEU (ERBB2) |
摘要 |
The present disclosure relates generally to methods for the detection and quantitation of the p95 component of HER2/neu (ERbB2). Such methods may comprise assaying the biological sample for expression of HER2 ICD; assaying the biological sample for expression of a HER2 ECD; quantitating an expressed amount of the HER2 ICD and an expressed amount of the HER2 ECD in the biological sample; and determining the amount of p95 expressed in the biological sample based on a difference between the expressed amount of the HER2 ICD and the expressed amount of the HER2 ECD. The methods of the present disclosure may be used to predict whether a subject will be responsive to a receptor tyrosine kinase inhibitor and/or may be used to select subjects for inclusion/exclusion in a clinical trial.
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申请公布号 |
US2010332417(A1) |
申请公布日期 |
2010.12.30 |
申请号 |
US20100792027 |
申请日期 |
2010.06.02 |
申请人 |
TARGETED MOLECULAR DIAGNOSTICS, LLC |
发明人 |
BACUS SARAH S. |
分类号 |
A61K39/395;A61K31/517;A61K31/5377;A61P35/00;G01N33/53;G01N33/567;G01N33/574;G06Q90/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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