| 发明名称 |
BENZAMIDE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS |
| 摘要 |
The invention concerns a compound of the formula (I) wherein Ring A is heterocyclyl; m is 0-4 and each R1 is a group such as hydroxy, halo, trifluoromethyl and cyano; R2 is halo and n is 0-2; and each R4 is a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0-4; and R3 is amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical condions mediated by histone deacetylase.
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| 申请公布号 |
US2010331329(A1) |
申请公布日期 |
2010.12.30 |
| 申请号 |
US20100879367 |
申请日期 |
2010.09.10 |
| 申请人 |
ASTRAZENECA AB |
发明人 |
STOKES ELAINE SOPHIE ELIZABETH;ROBERTS CRAIG ANTHONY;WARING MICHAEL JAMES |
| 分类号 |
A61K31/5377;C07D251/14;A61K31/341;A61K31/426;A61K31/427;A61K31/435;A61K31/4365;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/444;A61K31/445;A61K31/4465;A61K31/451;A61K31/4525;A61K31/453;A61K31/454;A61K31/47;A61K31/4709;A61K31/4725;A61K31/495;A61K31/496;A61K31/4965;A61K31/497;A61K31/505;A61K31/506;A61K31/519;A61K31/52;A61K31/53;A61K31/5375;A61P7/06;A61P25/14;A61P35/00;A61P43/00;C07D211/34;C07D213/56;C07D213/74;C07D215/12;C07D215/14;C07D237/08;C07D239/26;C07D239/30;C07D239/38;C07D239/42;C07D241/12;C07D241/18;C07D241/20;C07D251/18;C07D251/48;C07D265/30;C07D277/20;C07D277/24;C07D277/30;C07D295/14;C07D295/155;C07D307/54;C07D401/04;C07D401/06;C07D401/12;C07D403/12;C07D405/06;C07D407/06;C07D409/04;C07D413/04;C07D413/06;C07D413/12;C07D417/06;C07D473/00;C07D487/04;C07D495/04 |
主分类号 |
A61K31/5377 |
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