发明名称 |
CYCLIC PEPTIDES AS G-PROTEIN COUPLED RECEPTOR ANTAGONISTS |
摘要 |
The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.
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申请公布号 |
US2010331236(A1) |
申请公布日期 |
2010.12.30 |
申请号 |
US20090502937 |
申请日期 |
2009.07.14 |
申请人 |
PROMICS PTY LIMITED;UNIQUEST PTY LIMITED |
发明人 |
TAYLOR STEPHEN MAXWELL;SHIELS IAN ALEXANDER;FAIRLIE DAVID;MARCH DARREN;WHITEHOUSE MICHAEL |
分类号 |
A61K38/00;A61K38/12;A61P1/02;A61P9/10;A61P11/00;A61P11/06;A61P17/00;A61P17/04;A61P17/06;A61P19/02;A61P25/00;A61P25/28;A61P29/00;A61P31/04;A61P37/00;A61P37/02;A61P37/06;A61P43/00;C07K7/54;C07K7/56;C07K7/64;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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