Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt therof wherein the substituent G is a adamantyl, or a bicyclic or a tricyclic group of formula (III) and the remaining substituents are as defined in the specification. Also disclosed is the use of the compounds for treating muscarinic receptor mediated diseases such as CNS derived pathologies, Attention Deficit Hyperactivity Disorder (ADHD), obesity, Alzheimer's disease and dementia.
申请公布号
NZ553202(A)
申请公布日期
2010.12.24
申请号
NZ20050553202
申请日期
2005.08.19
申请人
VERTEX PHARMACEUTICALS, INCORPORATED
发明人
MAKINGS, LEWIS R;GARCIA-GUZMAN BLANCO, MIGUEL;HURLEY, DENNIS J;DRUTU, IOANA;RAFFAI, GABRIEL;BERGERON, DANIELE M;NAKATANI, AKIKO;TERMIN, ANDREAS P;SILINA, ALINA