发明名称 |
USES OF PENTAMIDINE AND RELATED COMPOUNDS |
摘要 |
Methods are provided herein for treatment of myotonic dystrophy and other toxic RNA diseases in a subject. In some examples, the method comprises administration of a compound that binds a nucleotide repeat expansion in a ribonucleic acid molecule, thereby treating the disease. In additional examples, the method comprises administration of a compound that disrupts binding of muscleblind-like proteins to an RNA nucleotide repeat expansion. Compounds for use in the disclosed method include pentamidine or heptamidine or derivatives thereof. Representative compounds are described herein.
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申请公布号 |
US2010323993(A1) |
申请公布日期 |
2010.12.23 |
申请号 |
US20090918696 |
申请日期 |
2009.02.20 |
申请人 |
BERGLUND JOHN ANDREW;WARF BRYAN M;MATTHYS CATHERINE;HALEY MICHAEL M;HILTON CAMERON L |
发明人 |
BERGLUND JOHN ANDREW;WARF BRYAN M.;MATTHYS CATHERINE;HALEY MICHAEL M.;HILTON CAMERON L. |
分类号 |
A61K31/155;A61K31/341;A61K31/655;A61P21/00;A61P25/28 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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