发明名称 |
METHODS FOR MODULATING A POPULATION OF MYELOID-DERIVED SUPPRESSOR CELLS AND USES THEREOF |
摘要 |
The invention provides for methods of modulating a population of myeloid-derived suppressor cells (MDSCs) in a subject, for treating an autoimmune disease, and also treating cancer in a subject in need thereof. The methods comprise administering to the subject a therapeutically effective amount of an agent that modulates the Tim-3 pathway. The Tim-3 pathway can be activated by a Tim-3 ligand, galectin-9, whereby MDSCs are expanded, or inhibited by an antibody to Tim-3, wherein the expansion of MDSCs is inhibited. |
申请公布号 |
WO2009097394(A3) |
申请公布日期 |
2010.12.23 |
申请号 |
WO2009US32372 |
申请日期 |
2009.01.29 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;KUCHROO, VIJAY;ANDERSON, ANA;DARDALHON, VALERIE |
发明人 |
KUCHROO, VIJAY;ANDERSON, ANA;DARDALHON, VALERIE |
分类号 |
A61K38/17;A61P31/04;A61P31/10;A61P31/12;A61P33/00;A61P35/00;A61P37/04;A61P37/06;C07K16/28 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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