MAGNETIC CHIRAL STATIONARY PHASE HAVING THE NANO SILICA PARTCLES AND THE SEPARATION METHOD OF THE RACEMIC COMPOUND IN USE OF IT

摘要

PURPOSE: A method for separating an optical isomer using magnetic silica particles-attached magnetic chiral solid phase(MCSP) is provided to control and separate optical isomers including pharmacetuical products using a magnet. CONSTITUTION: A magnetic silica particle-attached magnetic chiral solid phase(MCSP) has an optically acid chiral selector. The chiral selector is a chiral amino acid or derivative thereof having an optical activity, chiral crown ether having an optical activity or derivative thereof, or alpha, beta, or gamma cyclodextrin or derivative thereof having an optical activity. A method for separating the optical isomer using a magnetic chiral solid phase comprises: a step of preparing magnetic silica particle-attached magnetic solid phase phase(MCSP); a step of inputting the MCSP to a solution containing optical isomer; and a step of separating the magnetic chiral solid phase using the magnetic.