CATIONIC LIPOSOME DELIVERY OF TAXANE TO ANGIOGENIC BLOOD VESSEL

摘要

PROBLEM TO BE SOLVED: To provide a method of selectively affecting angiogenic endothelial cells. SOLUTION: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs comprising promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell. The present invention can be used in the treatment of cancer, wound healing, and a variety of chronic inflammatory diseases. COPYRIGHT: (C)2011,JPO&INPIT