PIPERAZINE-QUINOLINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT

摘要

PURPOSE: A pharmaceutical composition containing piperazine-quinoline derivative for preventing or treating central nervous system diseases is provided to enhance high affinity to 5-HT6 receptor. CONSTITUTION: A piperazine-quinoline derivative is denoted by chemical formula 1. A method for preparing piperazine-quinoline derivative comprises: a step of reacting a compound of chemical formula 2 with a compound of chemical formula 3 or 4 to obtain a compound of chemical formula 5; a step of cycling the compound of chemical formula 5 to prepare a compound of chemical formula 6; a step of intoruding piperazinyl group to the compound of chemical formula 6 to obtain a compound of chemical formula 7; and a step of introducing sulfonyl group to the amine group of the compound of chemical formula 7. A pharmaceutical composition for preventing or treating central nervous system(CNS) diseases contains the piperazine-quinoline derivative of chemical formula 1.