发明名称 |
High Concentration Factor VII Polypeptide Formulations Comprising an Aromatic Preservative and an Antioxidant |
摘要 |
The present invention relates to pharmaceutical compositions comprising at least 10 mg/mL of a Factor VII polypeptide (i); a buffering agent (ii) suitable for keeping pH in the range of from about 5.0 to about 9.0; at least one aromatic preservative (iii) in a concentration of at least 0.1 mg/mL; and at least one antioxidant (iv) in a concentration of at least 0.1 mg/mL; the composition optionally comprising further components, with the proviso that none of such further components are Factor VII polypeptide stabilizing agents selected from (a) metal-containing agents, wherein said metal is selected from the group consisting of first transition series metals of oxidation state +II, except zinc; and (b) stabilising agent comprising a—C(═N—Z1-R1)-NH—Z2-R2 motif.
|
申请公布号 |
US2010294677(A1) |
申请公布日期 |
2010.11.25 |
申请号 |
US20080598518 |
申请日期 |
2008.04.30 |
申请人 |
NOVO NORDISK HEALTH CARE AG |
发明人 |
RISCHEL CHRISTIAN;JENSEN MICHAEL BECH;NIELSEN ANDERS DYBDAL |
分类号 |
B65D69/00;A61K38/48;A61P7/04;B65D85/00 |
主分类号 |
B65D69/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|