发明名称 |
A SYNTHETIC METHODOLOGY FOR THE REDUCTIVE ALKYLATION AT THE C-3 POSITION OF INDOLES |
摘要 |
A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substituents at the N-1 position. |
申请公布号 |
ZA200604966(B) |
申请公布日期 |
2010.11.24 |
申请号 |
ZA20060004966 |
申请日期 |
2006.06.15 |
申请人 |
WYETH LLC |
发明人 |
MICHALAK RONALD STANLEY;RAVEENDRANATH PANOLIL |
分类号 |
C07D;C07D209/18;C07D209/22;C07D413/02;C07D417/02;C07D493/10 |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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