发明名称 |
COMPOSITIONS AFFECTING HYALURONIC ACID MEDIATED ACTIVITY |
摘要 |
Compositions comprising hyaluronic acid (HA) or agents that interfere with HA binding of HA receptors and methods of using the same are provided. For example, there is provided a composition comprising HA oligomers ranging in size from 10-mer to 80-mer and use of the same for promoting migration, growth or survival of wild-type or transformed/cancerous cells. There is also provided a composition comprising an agent that interferes with binding between an HA oligomer of a size of about 10-mer to about 80-mer and an HA receptor. Such compositions may be useful for therapeutic, diagnostic or imaging applications. Examples of therapeutic use are wound repair or cancer treatment.
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申请公布号 |
US2010290989(A1) |
申请公布日期 |
2010.11.18 |
申请号 |
US20080682774 |
申请日期 |
2008.10.10 |
申请人 |
LONDON HEALTH SCIENCES CENTRE RESEARCH INC.;REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
TOLG CORNELIA;TURLEY EVA;MCCARTHY JIM;LUYT LEONARD G. |
分类号 |
A61K51/00;A61K31/715;A61K38/00;A61K49/00;A61P35/00;C07H3/00;C07K2/00;G01N33/566;G01N33/574 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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