The present invention is concerned with isoxazole-pyridine derivatives of formula I, having affinity and selectivity for GABA A a5 receptor, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
申请公布号
WO2010127976(A1)
申请公布日期
2010.11.11
申请号
WO2010EP55695
申请日期
2010.04.28
申请人
F. HOFFMANN-LA ROCHE AG;JAKOB-ROETNE, ROLAND;LUCAS, MATTHEW, C.;THOMAS, ANDREW
发明人
JAKOB-ROETNE, ROLAND;LUCAS, MATTHEW, C.;THOMAS, ANDREW