| 摘要 |
<p>The present invention is concerned with novel isoxazole derivatives of formula (I) wherein X, R1, R2, R3 and R4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A a5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula (I), pharmaceutical compositions containing them and their use as medicaments.</p> |
| 申请人 |
F. HOFFMANN-LA ROCHE AG;BUETTELMANN, BERND;JAKOB-ROETNE, ROLAND;KNUST, HENNER;LUCAS, MATTHEW C.;THOMAS, ANDREW |
发明人 |
BUETTELMANN, BERND;JAKOB-ROETNE, ROLAND;KNUST, HENNER;LUCAS, MATTHEW C.;THOMAS, ANDREW |
