| 摘要 |
PROBLEM TO BE SOLVED: To provide poly-pegylated protease inhibitors. SOLUTION: There are provided compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also the related methods are provided. The compound has a molecular weight of 12, 14 or 16 kDa. In one embodiment, each non-protein moiety has an average molecular weight of 3-20 kDa, 3-12 kDa, 3-10 kDa, 3-8 kDa or 4-6 kDa, e.g. about 4, 5, 6, 7 or 8 kDa. COPYRIGHT: (C)2011,JPO&INPIT |
