发明名称 |
Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer |
摘要 |
A novel micellar preparation in which the solubility of a sparingly water-soluble anticancer agent has been heightened and which after intravenous administration, enables a high blood concentration to be maintained. The preparation has high medicinal activity and/or is reduced in side effects. The micellar preparation is formed from a block copolymer represented by the following general formula (1): [wherein R1 represents hydrogen or C1-5 alkyl; R2 represents C1-5 alkylene; R3 represents methylene or ethylene; R4 represents hydrogen or C1-4 acyl; R5 represents hydroxyl, optionally substituted aryl C2-8 alkoxyl, substituted C1-4 alkylamino, or amino having a residue of either an amino acid or a peptide derivative; n is an integer of 5 to 1,000; m is an integer of 2 to 300; and x is an integer of 1 to 300; provided that the proportion of hydroxy in the R5's is 0 to 99% and x is not larger than m] and a sparingly water-soluble anticancer agent.
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申请公布号 |
US7820759(B2) |
申请公布日期 |
2010.10.26 |
申请号 |
US20090322322 |
申请日期 |
2009.01.30 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA;NANOCARRIER KABUSHIKI KAISHA |
发明人 |
SHIMIZU KAZUHISA;MURATA TOSHITAKA;SAGAWA KATSUHIKO |
分类号 |
A61K47/48;A61K31/337;A61K47/42;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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地址 |
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