发明名称 |
Use of trifunctional bispecific antibodies for the treatment of tumors associated with CD133+/EpCAM+ cancer stem cells |
摘要 |
Use of a trifunctional bispecific antibody having the following properties of: a) binding to a T cell; b) binding to EpCAM as tumor-associated antigen on a tumor cell wherein the tumor cell additionally carries the membrane bound glycoprotein CD133; c) binding by its Fc portion to Fc receptor-positive cells for the preparation of a pharmaceutical composition for the destruction of cancer stem cells carrying the tumor-associated antigen EpCAM and the membrane bound glycoprotein CD133 in a population of patients suffering from a tumor.
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申请公布号 |
EP2241576(A1) |
申请公布日期 |
2010.10.20 |
申请号 |
EP20090158179 |
申请日期 |
2009.04.17 |
申请人 |
TRION PHARMA GMBH |
发明人 |
LINDHOFER, HORST |
分类号 |
C07K16/28;C07K16/30;C07K16/46 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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