Semisyntetiske taksaner med antitumor, antiangiogenetiske og anti-artrose aktiviteter, farmasoytiske sammensetninger inneholdende dem og anvendelse av forbindelsene

摘要

Seco-baccatin III derivatives of formula: wherein R, R₁-R₄, R¹ R', R¹¹ R'', and R¹¹¹ R''' are disclosed herein; pharmaceutical compositions comprising seco-baccatin III derivative; and methods for treating cancer, arthritis, and inhibiting angiogenesis in an animal comprising administrating to a patient in need thereof a therapeutically effective amount of a seco-baccatin III derivative are disclosed.