| 摘要 |
PROBLEM TO BE SOLVED: To provide diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. SOLUTION: The diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers are provided. The methods and uses can further include detecting p53 expression. Also, reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding are provided. A method is for diagnosing a cancer in a subject. The method includes detecting COP1 levels or COP1 activity in the cancer in the subject. COPYRIGHT: (C)2011,JPO&INPIT
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