RECOMBINANT BCG TUBERCULOSIS VACCINE FOR ELICITING IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS
摘要
<p>A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.</p>
申请公布号
EP2235163(A1)
申请公布日期
2010.10.06
申请号
EP20080853526
申请日期
2008.11.26
申请人
AERAS GLOBAL TB VACCINE FOUNDATION
发明人
SHAFFERMAN, AVIGDOR;ZVI, ANAT;ARIEL, NAOMI;FULKERSON, JOHN;SUN, RONGGAI;CHANG, ROSEMARY;SADOFF, JERALD, C.