RAPID ANTEMORTEM DETECTION OF INFECTIOUS AGENTS

摘要

Methods for detection of the presence or absence of PrPSc in a biological sample suspected of having them comprising the steps of concentrating the PrPSc as may be present in the sample by substantially separating the PrPSc from the sample matrix; labeling the concentrated PrPSc with at least one molecular label to produce labeled PrPSc; and detecting the labeled PrPSc on an instrument capable of detecting an attomole quantity of labeled PrPSc, and wherein the duration of time between concentrating the PrPSc and analyzing the labeled PrPSc is about 48 hours or less.