PREPARATION PROCESS OF ACETYLENE DERIVATIVE

摘要

PURPOSE: A producing method of an acetylene derivative is provided to easily produce a metal-acetylide nucleophile using a decarboxylation reaction from a propiolic acid derivative without using large amount of bases. CONSTITUTION: A producing method of an acetylene derivative marked with chemical formula 1 comprises the following steps: forming organic silver salt marked with chemical formula 4, by reacting silver salt marked with chemical formula 3 and a propiolic acid derivative marked with chemical formula 2; and reacting the organic silver salt with a compound containing palladium salt, a phosphine group ligand, and an organic halide compound marked with chemical formula 5.