发明名称 |
Methods and Compositions for Ameliorating Diabetes and Symptoms Thereof |
摘要 |
The present invention relates generally to the Tlr4 signaling pathway specifically in the hematopoietic system and its contribution to insulin resistance of liver and adipose tissue. The hematopoietic component expressing Tlr4 is a principle propagator of immune signaling and results in insulin resistance. Furthermore, disclosed herein are methods and compositions for treating or preventing disorders associated with insulin resistance using a Tlr4 antagonist.
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申请公布号 |
US2010239589(A1) |
申请公布日期 |
2010.09.23 |
申请号 |
US20100711073 |
申请日期 |
2010.02.23 |
申请人 |
SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
WOODS NIELS-BJARNE;SABERI MAZIYAR;OLEFSKY JERROLD M.;VERMA INDER M.;DE LUCA CARL |
分类号 |
A61K39/395;A61P3/00;A61P3/04;A61P3/10;A61P9/00;C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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