发明名称 |
ENZYME-PRODRUG THERAPY FOR PROSTHETIC JOINT REPAIR |
摘要 |
The invention relates to the use of gene therapy in the treatment of aseptic loosening of orthopaedic prostheses and discloses methods of refixing such prostheses without open revision surgery. In particular, it provides adenoviral vectors and prodrugs for simultaneous, separate or sequential use in the destruction of interface tissue allowing subsequent recementing of loose prostheses in a minimally invasive manner.
|
申请公布号 |
US2010240737(A1) |
申请公布日期 |
2010.09.23 |
申请号 |
US20100689263 |
申请日期 |
2010.01.19 |
申请人 |
HUIZINGA TOM J W;HOEBEN ROBERT C;NELISSEN ROB G H H;MOUNTAIN ANDREW |
发明人 |
HUIZINGA TOM J.W.;HOEBEN ROBERT C.;NELISSEN ROB G.H.H.;MOUNTAIN ANDREW |
分类号 |
A61K31/7088;A61F2/28;A61F2/30;A61F2/32;A61F2/46;A61K47/48;A61K48/00;C12N15/861 |
主分类号 |
A61K31/7088 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|