发明名称 |
Targeting Bacterial Suicide Pathways for the Development of Novel Antibiotics |
摘要 |
The invention provides methods for identifying an agent which prevents or partially prevents an antitoxin from forming a complex with its cognate toxin, comprising contacting a potential agent with a labeled substrate in solution, whereby detection of the label indicates presence of an agent that prevents an antitoxin from forming complex with a toxin. The invention also provides agents capable of interfering with formation of a toxin-antitoxin complex. Such agents act as novel, non-conventional antibiotics against human pathogenic bacteria.
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申请公布号 |
US2010234287(A1) |
申请公布日期 |
2010.09.16 |
申请号 |
US20070293838 |
申请日期 |
2007.03.22 |
申请人 |
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
INOUYE MASAYORI;WOYCHIK NANCY;INOUE KOICHI |
分类号 |
A61K38/00;A61K38/16;C07K2/00;C07K14/00;C12N1/20;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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