摘要 |
The invention relates to novel heteroaryl carboxamides of formula (I) and salts, hydrates or solvates thereof, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory. (see formula I) In formula (I), R1 is an azabicyclo[m.n.o]alkyl radical having 7 to 11 ring atoms, in which m, n and o are identical or different and are 0, 1, 2 or 3, and where the radical is optionally substituted by (C1-C6)-alkyl; the ring A is pyrimido, or is optionally benzo-fused pyrido, pyridazo or pyrazino; and R2 and R3 are identical or different radicals, wherein the radical is hydrogen, halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, (C1-C6(-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylthio, (C3-C8)-cycloalkyl, 4- to 8-membered heterocyclyl, phenyl or 5-to 6-membered heteroaryl, where phenyl and heteroaryl are optionally substituted by halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, amino, mono- or di-(C1-C4)-alkylamino, (C1-C4)-alkanoylamino or (C1-C4)-alkanesulfonylamino.
|
申请人 |
BAYER HEALTHCARE AG |
发明人 |
HENDRIX, MARTIN;BOESS, FRANK-GERHARD;ERB, CHRISTINA;KRUEGER, JOACHIM;LUITHLE, JOACHIM;METHFESSEL, CHRISTOPH;SCHREIBER, RUDY;WIESE, WELF-BURKHARD |