| 摘要 |
Method for determination of energy modulation effect of preparations of different chemical structures at cardio-toxic effect of sodium nitroprusside in rats by means of investigation of blood. In 30 minutes before introduction of sodium nitroprusside in dose 20 mg/kg intraperitoneally one introduces cardyotril – 5 mg/ml, its metabolite – 5 mg/ml, ATF-long – 10 mg/ml. In 60 minutes after application of sodium nitroprusside one determines content of malate, azocytrate, piruvate, lactate, activity of KFK-ct, KFK-mh, malatdehydrogenase and at change of those characteristics oe determines energy-modulating effect of preparations as cardio-toxic effect of sodium nitroprusside in rats. |
