Glucose sensitive regulator of insulin transcription

摘要

A glucose sensitive regulator of insulin transcription includes a glucose response element (GIRE) of a liver-pyruvate (L-PK) gent promoter, and an insulin-sensitive element of an insulin-like growth factor binding protein-1 (IGFBP-1) basal promoter. The transcriptional activity of the regulator is stimulated by glucose and inhibited by insulin.