发明名称 VERWENDUNG VON ANTAGONISTEN-ANTI-CD40-MONOKLONALEN ANTIKÖRPERN ZUR BEHANDLUNG VON MULTIPLEM MYELOM
摘要 <p>Methods of therapy for treating a subject for multiple myeloma are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti- antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40 expressing multiple myeloma cells.</p>
申请公布号 DE602004028272(D1) 申请公布日期 2010.09.02
申请号 DE20046028272T 申请日期 2004.11.04
申请人 NOVARTIS VACCINES AND DIAGNOSTICS INC. 发明人 LONG, LI;LUQMAN, MOHAMMAD;YABANNAVAR, ASHA;ZAROR, ISABEL
分类号 A61K39/395;C07K16/28 主分类号 A61K39/395
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