POLYAMINE INHIBITORS FOR THE TREATMENT AND PREVENTION OF PARKINSON'S DISEASE

摘要

Disclosed herein are methods for treating a disease involving a-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce a-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce a-synucleic aggregation; or (3) a compound which inhibits a- synucleic aggregation in an amount effective to reduce a-synucleic aggregation. Also disclosed are methods for reducing the amount of a-synucleic aggregation in a brain cell using (1) a compound which reduces the amount of polyamines in an amount effective to reduce a-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce a-synucleic aggregation; or (3) a compound which inhibits a-synucleic aggregation in an amount effective to reduce a-synucleic aggregation. Disclosed herein are also compounds which can be used in the above described methods.