发明名称 |
ETHACRYNIC ACID-CONTAINING COMPOSITION AND METHOD FOR PREVENTION AND TREATMENT OF TRANSGLUTAMINASE-RELATED DISEASES |
摘要 |
The present invention relates to ethacrynic acid and a transglutaminase inhibitor comprising a pharmaceutically acceptable salt of ethacrynic acid; more particularly, to ethacrynic acid for inhibiting the activity of transglutaminase involved in the pathogenesis of diseases in cases of altered expression, a transglutaminase inhibitor comprising a pharmaceutically acceptable salt of ethacrynic acid, and to a novel use of thereof. According to the present invention, there are provided ethacrynic acid, a transglutaminase inhibitor comprising active components of a pharmaceutically acceptable salt of ethacrynic acid and a transglutaminase inhibition method. The present ethacrynic acid, transglutaminase inhibitor comprising a pharmaceutically acceptable salt of ethacrynic acid or ethacrynic acid itself, and transglutaminase inhibition method provide a safer application without side effects to a patient having a disease where altered expression of transglutaminase is observed, thereby providing the inhibitory effect on transglutaminase. |
申请公布号 |
WO2010062144(A3) |
申请公布日期 |
2010.08.19 |
申请号 |
WO2009KR07057 |
申请日期 |
2009.11.27 |
申请人 |
NATIONAL CANCER CENTER;KIM, SOO YOUL;LEE, CHANG HOON;LEE, BYUNG IL;JEONG, KYUNG CHAE |
发明人 |
KIM, SOO YOUL;LEE, CHANG HOON;LEE, BYUNG IL;JEONG, KYUNG CHAE |
分类号 |
A61K31/192;A61P35/00 |
主分类号 |
A61K31/192 |
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